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Field
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and Pacific Biosciences platforms, single-cell multi-omics, 3D genome architecture studies (e.g., Micro-C and HiC), CUT&RUN and CUT&Tag. Experimental systems will include CRISPR/Cas9-mediated genetic
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-leading research in several fields. Notably, the groundbreaking discovery of the CRISPR-Cas9 gene-editing tool, which was awarded the Nobel Prize in Chemistry, was made here. At Umeå University, everything
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disorders using brain organoids derived from human induced pluripotent stem cells (hiPSCs). The Meng lab integrates brain organoid models with CRISPR-Cas9-based genetic screening, antisense oligonucleotide
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multidisciplinary approaches, including CRISPR-based functional genomics, stable isotope tracing, metabolomics, molecular and cellular biology, biochemistry, and mouse models to investigate how nucleotide metabolism
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-erythrocytic and transmission stages of the parasite lifecycle. Current projects include CRISPR/Cas9-based parasite engineering, functional characterization of parasite genes involved in liver infection and
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. Joost Smolders at MS Center ErasMS in Rotterdam. The project combines functional genetics in primary human B cells and B cell lines (CRISPR-KO and knock-in base editing) with immunological co-culture
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already in place: Existing genome-wide CRISPR screening data from RLT and EBRT models, with compelling hits already identified and a clear path towards clinical translation Isogenic radio-resistant and
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-resolution microscopy Genome editing (e.g., CRISPR-based approaches) Quantitative and live-cell imaging Functional genomics The project is embedded in an interdisciplinary research environment combining
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, Cell & Molecular Biology or related field. Post doctoral Associate less than 2 year from date of Ph.D. conferral date. Experience in CRISPR based functional genomics, iPSC derived organoids, and murine
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the other postdoc included in the project. Main tasks of the postdoc Culture M. leidyi and use CRISPR-cas9 to obtain knockout strains Perform common garden experiments testing wildtype vs knockout strains