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therapeutic editing strategies. Research Focus Areas Neurodevelopmental disorders and the genetic and epigenetic mechanisms underlying altered neural development. Genome and epigenome editing (e.g., CRISPR
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biology ● Mitochondrial and metabolic biology ● Neurobiology and glial biology ● Neuroimmune interactions ● Human genetics and functional genomics ● Single-cell and spatial omics ● CRISPR
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, and therapeutic engineering. Projects may involve immunotherapy models, CRISPR-based perturbation and screening, mRNA therapeutics and vaccines, protein engineering, systems immunology, and tumor
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. Building on this platform, we combine cell biology, biochemistry, CRISPR-based approaches, organelle isolation, metabolomics and proteomics, mouse genetics, and disease models to discover principles of ER
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mechanistic interrogations using models, such as conditional knock-out or CRISPR-mediated targeted insertion. The goal is to understand T cell homeostasis in the context of viral infection, chronic infection
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mammalian riboswitches and defining their biological functions. Research activities may include: Genetic manipulation of mammalian cell lines using CRISPR-based approaches Construction and analysis
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approaches such as non-coding CRISPR screens, the Massively Parallel Reporter Assay (MPRA), saturation mutagenesis, and synthetic sequence design, alongside machine-learning models of regulatory grammar
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) Familiarity with molecular cloning, viral vectors, or CRISPR-based gene editing Prior research in cerebrovascular or neurological diseases Appointment and Location: The position is based at the Anlyan Center in
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this, we use zebrafish CRISPR-generated mutants to perform high-throughput functional screens. The postdoctoral associate will also support other tasks related to the team’s research, including the following
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Postdoctoral Associate | Mitochondrial Genomics | Lake Lab — Yale University, Department of Genetics
, molecular and cellular biology, or a related field. Experience with cell culture and molecular biology techniques is required. Experience with one or more of the following is desired: CRISPR/genome editing