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Field
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including: CRISPR-based genetic screening High-throughput microscopy Confocal microscopy Flow cytometry and cell sorting Functional genomic profiling Contribute to in vivo studies using mouse models and
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Experience in knockout generation using CRISPR Experience in cellular and molecular immunology techniques, including flow cytometry, ex vivo Treg expansion, intracellular cytokine assays, and functional immune
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projects independently Ideal Candidates Experience with gene delivery (mRNA, DNA, CRISPR) Background in cartilage, ECM transport, or polyelectrolyte systems Prior exposure to translational or industry-linked
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biology ● Mitochondrial and metabolic biology ● Neurobiology and glial biology ● Neuroimmune interactions ● Human genetics and functional genomics ● Single-cell and spatial omics ● CRISPR
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Immunology, Systems Biology, or a related discipline Experience in knockout generation using CRISPR Experience in cellular and molecular immunology techniques, including flow cytometry, ex vivo Treg expansion
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, and therapeutic engineering. Projects may involve immunotherapy models, CRISPR-based perturbation and screening, mRNA therapeutics and vaccines, protein engineering, systems immunology, and tumor
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that variants have on PR-DUB and PRC1 function - using methods such as CUT&Tag, Captify, RNA-seq, immunoprecipitation followed by mass spectrometry and high throughput pooled CRISPR screens. The role
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and chromatin accessibility, CRISPR based gene and epigenetic perturbation, and deeply phenotype human cohorts to define causal mechanisms driving post infectious and post tuberculosis lung disease
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, to characterise the transition into senescence Studying how cell enlargement drives genome instability following senescence evasion or escape. Performing CRISPR screens to identify targetable vulnerabilities in
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to study protein-protein interactions, such as co-immunoprecipitation. Experience with genetic manipulation, including CRISPR-based approaches or related techniques, is highly desirable. Expertise in