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Field
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or the immune system. Experience in functional genomics using CRISPR/Cas9, including genome-wide screening and/or small-molecule screening, and candidate validation through loss- and gain-of-function approaches
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genetics, gene therapy, CRISPR-based gene editing, stem cell technologies, and translational disease modelling. We are particularly interested in developing treatments for retinal disorders prevalent in
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Postdoctoral position involving CRISPR-based screens, reporter assay development, and cellular phenotypic characterization. A postdoctoral position is immediately available in the laboratory of Dr
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Max Planck Institute of Molecular Physiology, Dortmund | Dortmund, Nordrhein Westfalen | Germany | about 1 month ago
biological pathways underlying the assembly of multimeric membrane proteins using CRISPR-based genetic screens, as well as mechanistic dissection using techniques from molecular biology, cell biology
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surveillance during early colorectal tumorigenesis. • Generate and manipulate human and mouse colorectal adenoma cells and organoid models. • Use CRISPR/Cas9, inducible gene-expression systems, miRNA inhibitors
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conduct independent and collaborative research on NIH-funded projects involving CRISPR-based genome editing, viral and nonviral delivery systems, tumor immunology, engineered extracellular vesicles, and
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cells, pericytes) to construct complex 3D assembloids and organ-on-a-chip platforms. • Mechanistic Dissection: Deploy CRISPR/Cas9 genome editing, shRNA/ASO tools, and pharmacological screens
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, together with experience in mammalian cell culture, CRISPR/Cas9 genome editing and genomic or epigenomic approaches. Experience analysing genomic datasets and a strong understanding of transcriptional and
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ability to work independently and collaboratively. Experience with plant RNA or DNA virus vectors, VIGS, or virus-induced gene editing. Experience with CRISPR-Cas reagent design and delivery in plants
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including: CRISPR-based genetic screening High-throughput microscopy Confocal microscopy Flow cytometry and cell sorting Functional genomic profiling Contribute to in vivo studies using mouse models and