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Field
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chronic obstructive lung disease by loss-of-function. One of the major areas of focus is autophagy enhancer drugs to clear the toxic misfolded protein. Over the last 10 years the lab has refined the use
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function and chronic obstructive lung disease by loss-of-function. One of the major areas of focus is autophagy enhancer drugs to clear the toxic misfolded protein. Over the last 10 years the lab has refined
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University of North Carolina at Chapel Hill | Chapel Hill, North Carolina | United States | 5 days ago
-Restricted-Feeding, and metabolism directly regulates autophagy and lifespan. Also, a secondary focus of this work will be on the oxidative stress response in the fly and rodents harboring an engineered
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millions of people to virus. 2. Developing novel gene therapies to target neuronal cell biology processes such as autophagy or neural circuits that go awry in brain disease. 3. Developing powerful
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autophagy, functions as a lysosomal degradation system responsible for eliminating aberrant cytoplasmic components. Within the autophagy process, SQSTM1/p62 assumes a crucial role by serving as a receptor
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University of Tennessee Health Science Center | Memphis, Tennessee | United States | about 20 hours ago
. Study the role of autophagy in disease pathogenesis. Conduct experiments to study the environment-host interactions, epigenetic disease markers, and ischemia reperfusion injury as well as other related
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of autophagy in the clearance of Alzheimer’s-linked tau protein. The post holder will support the principal investigator and research team with various experimental procedures, analysis of results and lab
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of skeletal disease and responses to injury. This is a highly collaborative project integrating expertise in inflammation, autophagy and genetics with collaborators in other schools at the University of Bristol
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project to study the role of autophagy in organelle homeostasis in fungi. Major goals include the development of an assay to monitor Golgi biogenesis and turnover to identify components involved in
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candidate will be involved in studying genes involved in autophagy. Experience with molecular biology (e.g., PCRs, restriction enzyme digests, cloning and transformations), biochemistry (e.g., immunoblotting