Details
Posted: 23-Mar-24
Location: Ann Arbor, Michigan
Salary: Open
Categories:
Staff/Administrative
Internal Number: 246646
A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.
Note: This appointment is part-time at 75% effort/30 hours per week.
The laboratory of Daniel Klionsky at the Life Sciences Institute is looking for an Assistant Research Scientist to oversee a research project to study the role of autophagy in organelle homeostasis in fungi. Major goals include the development of an assay to monitor Golgi biogenesis and turnover to identify components involved in selective degradation of secretory pathway organelles under basal and stress conditions. The approach will require expertise in cell and molecular biology along with molecular genetics and considerable experience with various microscopy techniques. The project is anticipated to require recombinant DNA techniques (e.g., cloning, PCR), strain construction (e.g., the generation of knockout and point mutants, fluorescent tagging of specific proteins), and protein analyses (e.g., immunoprecipitation, western blot, microscopy). Due to differences in the spatial arrangement of the secretory pathway you will have experience working with both S. cerevisiae and K. phaffii/P. pastoris. In addition to planning and performing experiments, you will oversee research performed by graduate and undergraduate students and will work collaboratively with other members of the laboratory. You will report directly to Dr. Klionsky and will work on-site.
Experimental responsibilities will include:
- Design experiments independently and in collaboration with other lab members
- Generation of yeast strains expressing mutant and fluorescently tagged proteins
- Development of microscopy-based assays for monitoring changes in organelle status
- Carrying out assays for macroautophagy
- Solving experimental problems that arise during any of the responsibilities
Non-experimental responsibilities will include:
- Provide consultation and advice to lab members in areas of expertise, particularly microscopy
- Maintain clear laboratory notebooks
- Provide detailed documentation so experiments can be replicated
- Follow laboratory best practices for safety and quality
- Help manage projects
- Assist or collaborate with the PI in preparing manuscripts and grants
- Ph.D. in molecular biology, cell biology, biochemistry, biophysics, or related discipline
- Minimum 5 years of experience of postdoctoral work related with S. cerevisiae and K. phaffii/P. pastoris
- Minimum 5 years of experience in cell and molecular biology techniques in organelle biogenesis and the secretory pathway
- Minimum 5 years of experience in confocal, fluorescence and electron microscopy using yeast as the model system
- Minimum 3 years of experience mentoring students and research staff
- Strong publication record in relevant work
- Prior experience working in a collaborative environment
Benefits at the University of Michigan
In addition to a career filled with purpose and opportunity, The University of Michigan offers a comprehensive benefits package to help you stay well, protect yourself and your family and plan for a secure future. Benefits include:
- A retirement plan that provides two-for-one matching contributions
- Many choices for comprehensive health insurance
- Dental and Vision Insurance
- Life insurance
- Long-term disability coverage
- Flexible spending accounts for healthcare and dependent care expenses
- Maternity and Parental Leave
The University of Michigan conducts background checks on all job candidates upon acceptance of a contingent offer and may use a third party administrator to conduct background checks. Background checks are performed in compliance with the Fair Credit Reporting Act.
Our mission at the Life Sciences Institute is to promote the understanding of the fundamental processes of life, and to pioneer new ideas to improve human health.
For more information on the Klionsky laboratory: https://www.lsi.umich.edu/science/our-labs/klionsky-lab
All applications for this position must be received Friday, March 29th by 11:59p.
The University of Michigan is an equal opportunity/affirmative action employer.
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About University of Michigan - Ann Arbor
A great university is made so by its faculty and staff, and Michigan is recognized as one of the best universities to work for in the country. The Michigan culture is known for engaging faculty and staff in all facets of the university to create a workplace that is vibrant and stimulating.For two consecutive years, the Chronicle of Higher Education has placed U-M in its "Great Colleges to Work For" survey. In particular, the university earns high marks for strong relations between faculty and administrators, a collaborative system of governance, strong pay and benefits, and a healthy work/life balance.
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