Postdoctoral Scholar Research

Updated: 3 months ago
Location: Saint Petersburg, FLORIDA
Job Type: FullTime

Posting Details

Department: Center for Aging and Brain Repair – 0-6155-000

College/Division: USF Health - Morsani College of Medicine

Salary Plan: Temporary

Hiring Salary/Salary Range: $47,844 

Job Summary:

Exosomes from Adipose-derived Stem Cells Modulate Age-dependent Progression of Tauopathies: NIH funded postdoctoral positions are available immediately to highly motivated individuals to participate in ongoing studies on Alzheimer's disease (AD). Our laboratory is focusing on the idea that changes in immune function that occur with aging is an important factor to examine when following the progression of Tauopathies associated with Alzheimer’s disease and related disorders.   Our lab focuses on examining the complex proteomic and functional phenotype of microglia and how this is affected by aging using mouse models of tauopathies.   Furthermore, we have discovered that exosomes derived from adipose derived stem cells are potent modulators of inflammation and have potential to serve as therapeutic interventions in age-related tauopathies.  

Job Duties:

Within the predetermined research scope and methodology, conduct research experiments in the field of Alzheimer’s disease to include:

  • Performing surgeries to create AD models
  • Running behavioral analysis of animals
  • Isolation of microglia
  • Assay microglia in culture and using proteomics
  • Assess brain pathology using immunohistochemistry

Collect and analyze data, including periodical/literature search and utilizing specialized skills in related field to analyze the collected data.

Participate/assist in manuscript writing for publication in scientific journals and/or presentations.  May also assist in grant writing.

Lab maintenance, including equipment maintenance, and ordering of supplies as needed.

Other duties as assigned, which may include attending Scientific Conferences and Meetings.

Relevant publications:

  • Flowers A, Bell-Temin H, Jalloh A, Stevens SM, Jr., Bickford PC (2017) Proteomic anaysis of aged microglia: shifts in transcription, bioenergetics, and nutrient response. J Neuroinflammation 14:96.
  • Nash KR, Lee DC, Hunt JB, Jr., Morganti JM, Selenica ML, Moran P, Reid P, Brownlow M, Guang-Yu Yang C, Savalia M, Gemma C, Bickford PC, Gordon MN, Morgan D (2013) Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy. Neurobiol Aging 34:1540-1548.
  • Patel NA, Moss LD, Lee J-Y, Tajiri N, Acosta S, Hudson C, Parag S, Cooper DR, Borlongan CV, Bickford PC (2018) Long noncoding RNA MALAT1 in exosomes drives regenerative function and modulates inflammation-linked networks following traumatic brain injury. Journal of Neuroinflammation 15:204.

 

QUALIFICATIONS:

Minimum :

  • Applicants must hold a Ph.D. or MD. Ph.D. in a related field from an accredited institution, and a strong background in neurobiology, molecular/cellular biology, or mouse behavior.
  • Previous experience in microglia function, protoemics or genomics, cell culture system, brain expression of viral proteins, confocal imaging, or learning and memory behavioral testing will be an asset.
  • Must meet university criteria for appointment to the rank of Postdoctoral Fellow.

The candidate should have a keen interest in understanding complex mechanisms underlying memory formation and storage in mouse models of Alzheimer’s disease.  Successful applicants will have the opportunity to work in a dynamic environment and train with experienced molecular, cellular, and behavior neuroscientists investigating various aspects of the nervous system function and dysfunction.

These positions are available for up to 2-3 years.

 



USF Health

Information for Applicants 

This position is subject to a Level 1 criminal background check.

Job Opening Number: 22860

Posting Date:  10/07/2019

Posting End Date: 01/11/2019

How To Apply 

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Equal Employment Opportunity 

USF is an equal opportunity, equal access academic institution that embraces diversity in the workplace.

Work Location 

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USF - Tampa Campus

About USF 

The University of South Florida System is a high-impact, global research system dedicated to student success.  The USF System includes three institutions:  USF; USF St. Petersburg; and USF Sarasota-Manatee.  The institutions are separately accredited by the Commission on Colleges of the Southern Association of Colleges and Schools.  All institutions have distinct missions and their own detailed strategic plans.  Serving over 48,000 students, the USF System has an annual budget of $1.6 billion and an annual economic impact of $4.4 billion.  USF is a member of the American Athletic Conference.

Working at USF 

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