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Field
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assays, single-cell transcriptomics, and HLA-immunopeptidomics. You will identify how ERAP2 variants and small-molecule modulators alter the peptidome on EBV-infected B cells and how this shifts
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, integrating transcriptomic, proteomic and imaging data to reconstruct developmental trajectories, identify cell-cell communication networks and uncover mechanisms regulating human fetal choroid plexus
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. They will include genetic manipulations (RNA interference, CRISPR), transcriptomic and proteomic approaches, protein analysis (immunolabeling, Western blot, immunoprecipitation, purification), imaging (real
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isolation, sequencing library preparation, quality control, transcriptomic analysis, or other omics-based approaches, are strongly encouraged to apply. Excellent written and verbal communication skills
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single-cell and spatial multi-omic datasets, integrating transcriptomic, proteomic and imaging data to reconstruct developmental trajectories, identify cell-cell communication networks and uncover
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support all aspects of the research project. Carry out algorithmic development and data analysis, including (but not limited to) single-cell and spatial transcriptomics. Implement state-of-the-art
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transcriptomic profiling of cell lines and human primary tissues. This work will provide important advances in our understanding of human blood stem cell biology in the context of normal and neoplastic
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-throughput functional genomics data sets on the genome, epigenome, and transcriptome in disease-relevant tissues/cells and use of computational approaches to integrate and analyze this data to identify
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with spatial transcriptomic and proteomic datasets to establish quantitative relationships between ECM structure, tissue mechanics, and cellular molecular states across cardiac aging. Computational and
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Genomics (prof. Thierry Voet), the student will furthermore use single-cell transcriptomics tools to identify the genes and gene products that drive AAV replication and packaging across time. Additionally