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regulator of cell differentiation and stemness. Aberrant differentiation leads to developmental defects and cancer. We hypothesize that aberrant differentiation that is perturbed by abnormal Wnt/β-catenin
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on the development of stem cell-derived immunoavoidant neural and neuroendocrine progenitor cells, including both pancreatic beta cells and CNS glia. Principal supervisor is Professor Steven Goldman, goldman
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Hematopoietic stem cells (HSCs) ensure the lifelong production of all blood cell types. With age, HSCs undergo functional and molecular changes that impair their regenerative capacity and contribute
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programme β-catenin is a central regulator of cell differentiation and stemness. Aberrant Wnt/β-catenin activity can drive developmental defects and cancer. This project tests whether context-specific
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Fully Funded PhD Position: Decoding Chromosome 1 Risk in AMD Using Stem Cell–Derived Retinal Models Host: Newcastle University (UNEW), UK Consortium: MSCA Innovative Training Network Pandora Start date
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cells. Proteomic approaches have identified several surface proteins that are overexpressed in glioblastoma stem cells compared with non-tumour cells, and whose role in glioblastoma biology remains to be
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expected to carry out advanced computational analyses. Our underlying model system is the in vitro differentiation of adipose tissue stem cells into adipocytes. The project is in collaboration with
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microphysiological systems (MPS), are rapidly emerging as transformative and strategic technologies with the potential to redefine the future of health and life sciences. By integrating stem cell biology, patient
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, Cambridge Stem Cell Institute, Cambridge Institute of Therapeutic Immunology and Infectious Disease, the LMB, Babraham, and Wellcome Sanger Institute. A Loke CTR Studentship will be held within the relevant
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secondments (lab exchanges). The doctoral candidate will utilize cutting-edge techniques: Cell and tissue culture (human primary and stem cell-derived retinal models) Molecular biology and biochemistry