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this will be addressed using advanced NMR methods. and integrative modelling, providing real- insights into conformational changes governing CB1R selectivity. This project offers the opportunity
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allosteric coupling, to exquisitely control signal routing. We integrate structural biology (NMR, X-ray, cryoEM) and biophysical techniques (FRET, ITC, BLI) with cellular readouts (TopFlash, BRET) and
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validate backbone integration by NMR, GPC, DSC, DMA, tensile testing, UV-Vis spectroscopy, and pump probe characterization. Design and characterize synergistic switching cascades (collaborative, competitive
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equipped with everything necessary for the successful completion of the proposed research. Some equipment has been recently renewed: 600 MHz NMR (2026), HRMS (2026), chiral HPLC (2026); other equipment will
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stopped-flow measurements and NMR and EPR spectroscopy. Duties also include preparing periodic reports, participating in project team meetings, and collaborating and communicating with the other members
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and natural product synthesis; provide expertise in 1D/2D NMR, mass spectrometry, and IR spectroscopy; mentor graduate and undergraduate researchers; lead collaborative research efforts; and publish
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. Background in the field of Organic and/or Organometallic chemistry. Experience in the analysis of organic compounds (especially NMR methods). Experience in synthetic molecular chemistry under inert gas. Good
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University of North Carolina at Chapel Hill | Chapel Hill, North Carolina | United States | 2 months ago
supports the instructional and research missions of the Chemistry Department through engagement with faculty and students by providing consultation and expertise in NMR experiment design and instrument
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University of North Carolina at Chapel Hill | Chapel Hill, North Carolina | United States | about 2 months ago
supports the instructional and research missions of the Chemistry Department through engagement with faculty and students by providing consultation and expertise in NMR experiment design and instrument
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while improving long-term performance. The project offers a unique opportunity to gain advanced training in rheological and dynamic mechanical analysis, solid-state NMR, and time-resolved structural