Researcher within

The University of Gothenburg tackles society’s challenges with diverse knowledge. 53 500 students and 6 500 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

At the Institute of Neuroscience and Physiology, at the Sahlgrenska Academy, we conduct research and education covering a wide range of knowledge areas. The institute comprises five different departments: Clinical Neuroscience, Health and Rehabilitation, Pharmacology, Physiology and Psychiatry and Neurochemistry.

The Institute of Neuroscience and Physiology, invites applications for a Researcher position within Neurochemistry at the Department of Psychiatry and Neurochemistry. 

The Neurochemistry laboratory at the Institute of Neuroscience and Physiology conducts neurochemical research targeted to understand the pathophysiology of Alzheimer's disease and other brain disorders. An important goal is to identify protein changes linked to the pathophysiology, known as biomarkers, which can be valuable to explore disease mechanisms, for diagnosis and to monitor treatment effects.

For the planned research the group uses state of the art NMR-spectroscopy to study large molecular complexes underlying basic cellular functions at the atomic level in combination with other structural biology methods and biophysical characterization. The group investigates macromolecular protein machines underlying essential cellular functions, e.g. protein quality control and their effect on misfolding- and aggregation-prone proteins underlying several different diseases, through biophysical and structural biology approaches e.g. high-resolution Nuclear Magnetic Resonance (NMR). Structural characterization, in-depth biophysical as well as functional analysis of post-translational modifications, protein-processing, and protein:protein interactions of disease related proteins like a-Synuclein and Tau towards identifying initial events of protein misfolding observed in neurodegenerative diseases.

The research project aims at advancing the molecular understanding of the function and regulation of the interplay between post translational modifications as well as protein processing within the physiological role of a-Synuclein and Tau to identify the molecular triggers underlying their disease related misfolding. To achieve this goal a plethora of techniques ranging from basic cell biology and biochemistry to advanced NMR-spectroscopy (solution and solid-state bio-NMR, in-cell NMR, small molecule NMR) and biophysical characterization. Methods in cell-biology, microbiology, molecular biology, bioinformatics, and biochemistry will also be used. We are looking for a colleague, that is highly motivated, scientifically independent, and creative, as well as capable of contributing to an interdisciplinary team environment.

The applicant must have completed a Swedish doctoral degree or must have a foreign degree corresponding to a Swedish doctoral degree.

A relevant scientific background in Chemistry, Biochemistry, Protein Biophysics, Structural Biology or related fields is mandatory. Previous work on related protein systems will be considered favorable. 

The successful candidate should have a strong background in infectious biology, molecular biology, biochemistry, and/or NMR spectroscopy possessing detailed experience in the following mandatory techniques:

• Experience in recombinant protein expression from different host-systems, ranging from standard bacterial expression to insect cells and mammalian cells as well as the ability to maintain insect and mammalian cell cultures
• Expert knowledge in solution NMR methods (e.g. assignment, data analysis, dynamics)
• Expert knowledge in sample preparation (isotope labelling, methyl-labelling)
• Documented knowledge in automated data procession and analysis
• Knowledge in cell biology, including handling of mammalian cell culture etc.
• Detailed knowledge in additional biophysical and structural biology techniques (g. CD-Spectroscopy, Surface-Plasmon Resonance or BLI, Fluorescence Spectroscopy, SEC-MALS)

Previous work with aggregation-prone disease-related proteins and their structural and/or functional characterization will be considered an advantage. The following expertise are considered favourable: 

• Experience in solid-state NMR-techniques
• Experience in in-cell NMR-techniques in mammalian cells
• Experience in proteomic analysis by Mass spectrometry techniques

Furthermore, a genuine interest in structure and dynamics or protein function is required. Co-Authorship in high impact journals such as Science or JACS is considered favorable.

Great importance will be placed on personal suitability. 

The employment is a permanent position, 100% of full-time, and is placed at the Institute of Neuroscience and Physiology. Starting date; as soon as possible or as agreed. Probationary employment may be applied.

In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system.

If you have questions regarding the employment please contact Professor/Chief Physician Kaj Blennow, phone +46 31 343 1791, e-mail; [email protected].

Manager in charge is Professor/Head of Department Henrik Zetterberg, phone; +46 768 672 647, e-mail; [email protected].

Application documents are not to be submitted through the contact persons.

Union representatives at the University of Gothenburg: http://www.gu.se/english/about_the_university/job-opportunities/union-representatives

Choosing a career in a foreign country is a big step. Thus, to give you a general idea of what we and Gothenburg have to offer in terms of benefits and life in general for you and your family/spouse/partner please visit:

https://www.gu.se/english/welcomeservices/staff
https://www.movetogothenburg.com/

In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline.

Please enclose PhD certificate with the application.

Closing date:2022-02-04

The University of Gothenburg promotes equal opportunities, equality and diversity.

Salary is determined on an individual basis.

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.