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alterations impact human lymphocyte development. By combining CRISPR-based genome engineering, induced pluripotent stem cells (iPSCs), and advanced thymus and bone marrow organoid systems, we study both
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. Assist in drafting presentations on research findings. Responsibilities Performs molecular biology and genomics experiments according to established laboratory protocols including CRISPR based genome
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will be the functional characterisation of non-coding regulatory elements in bone and cartilage cells. The successful candidate will use CRISPR-Cas9 genome editing in human cell models, including
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. Previous experience with molecular biology techniques (Western blots, qPCR/RNAseq), experience with gene editing(CRISPR), and DNA manipulation, are all preferred. The candidate should have hands
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. Synthetic Biology Applications: Gaining experience in building software tools that support synthetic biology research, including CRISPR/Cas systems, molecular engineering, and vaccine/therapeutic delivery
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– signaling – proteasome – ubiquitination – multiple myeloma – mantle cell lymphoma – cancer – immunology – inflammation – infection – streptococcus – CRISPR/Cas9 – proteomics – targeted therapy Website
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. The successful candidate should have extensive experience from experimental laboratory work in molecular cell biology using techniques such as cell culture, CRISPR/Cas9 based genome editing, protein expression and
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therapeutic editing strategies. Research Focus Areas Neurodevelopmental disorders and the genetic and epigenetic mechanisms underlying altered neural development. Genome and epigenome editing (e.g., CRISPR
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: General reproductive biology experience CRISPR/Cas9 experience Electroporation experience Reproductive immunology background, particularly ovarian or uterine tissue Primary cell culture experience Histology
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involves the use of diabetic mouse models, isolated primary islets, and stem cell-derived islets, employing techniques such as fluorescence microscopy, proteomics, RNAseq, CRISPR-Cas9, and genetically