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Field
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technician to support in vivo CRISPR screening. You will join the ERC Starting Grant project PowerPortrait, which aims to disentangle the regulation of a key immune cell—the macrophage—in health and disease
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on CRISPR-Cas to stop the spread of AMR-carrying plasmids in the important pathogen Klebsiella pneumoniae. Proof-of-concept work shows that this is theoretically possible, but challenges remain in discerning
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position The Laboratory of Causal Systems Immunology is looking for a PhD student or postdoctoral researcher to advance in vivo perturbational screening. We have developed single-cell CRISPR technologies
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, tumour-microenvironment interactions and mechanisms of treatment resistance. We take a multidisciplinary approach, integrating in vivo models, primary and patient-derived cell lines, drug and CRISPR
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technologies aimed at assessing, protecting, and repairing donor livers before transplantation. This PhD project is embedded within the multidisciplinary CRISPR-CRYSTAL consortium, bringing together experts in
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associate with specialization in immunology, cancer biology and/or radiation biology. The Postdoctoral Associate will work alongside a multidisciplinary team leveraging CRISPR screening, antibody discovery
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, CRISPR screening, and human disease systems. This is an opportunity to pursue high-impact, discovery-driven research in a rapidly expanding field, lead publications, build an independent scientific profile
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." • Develop and apply human pluripotent stem cell-derived kidney organoid models, CRISPR-Cas9 genome editing, and molecular and cellular biology techniques to investigate disease mechanisms. • Perform and
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techniques in cell culture (routine cell maintenance, transient transfections, preparation of nuclear extracts, utilization of CRISPR/Cas9) Assist with fluorescent imaging techniques, both biochemical and in
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systems, based on the use of CRISPR/Cas9, with the ultimate goal of malaria control by decreasing the reproductive potential of mosquito populations and will be involved in the development of innovative