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such as single cells transcriptomics and epigenetics to characterize molecular and cellular mechanisms. Using these approaches, we previously identified an essential role for specific subsets of stromal
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. Through this project, the applicant will be able to develop their knowledge in genetics, gene regulation, and epigenetics. The project will involve communicating and learning from clinician researchers who
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mammalian embryonic development, with a specific emphasis on mammalian pseudo-embryos, also known as gastruloids. Project Overview: Using cutting-edge microscopy, genomic and epigenetic techniques, we aim
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, combining lineage tracing and depletion models, flow cytometry, confocal microscopy and unbiased approaches such as single cells transcriptomics and epigenetics to characterize molecular and cellular
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and epigenetic information. Our work combines epigenomic and transcriptomic technologies with advanced imaging and genetic engineering to investigate the establishment, maintenance and transformation