Postdoctoral position in inflammation /regeneration

Our laboratory has one position available for postdoctoral fellow in the area of inflammation and regenerative disease research. We are interested in mechanisms of immunoregulation and tissue adaptation to external challenges, with an emphasis on tissue long lived cells such as stromal cells, and their crosstalk with immune cells, stem cells and the vasculature. We perform mostly in vivo studies, combining lineage tracing and depletion models, flow cytometry, confocal microscopy and unbiased approaches such as single cells transcriptomics and epigenetics to characterize molecular and cellular mechanisms. Using these approaches, we previously identified an essential role for specific subsets of stromal cells in tissue repair and cancer immunity (Dulauroy et al., Nature Medicine 2012; Stzepourginski et al., PNAS 2017; Jacob et al., Cell Stem Cell 2022; Di Carlo et al., Nature Immunology 2023). Building on these findings, we aim at identifying novel mechanisms regulating tissue response to injury, with a focus on stromal immunoregulation and plasticity in organs with high remodeling capacity such as the skin, skeletal muscle or adipose tissue.

For more information and to apply, send a motivation letter, CV and contact information for 2 references to Lucie Peduto ([email protected] ).

Recent PhD or MD/PhD degree in vascular biology, immunology or related biomedical field, with a track record of publications and lab experience in one or more areas that include: vascular biology, innate immunity, stromal/mesenchymal stem cells, tissue repair. Highly motivated candidates with interest in areas of research at the intersection of immunology, vascular biology and stromal/stem cell biology are strongly encouraged to apply. Specific requirements:

• Required : Solid experience with in vivo rodent models and flow cytometry
• Desirable : Previous experience in transcriptomics analysis (scRNAseq), murine models for disease
• Would be a plus: Previous experience in scripting languages (R) and Seurat.

The position is available starting immediately. Benefits include comprehensive healthcare coverage. Research will be conducted at Institut Pasteur in the center of Paris, which contains state of-the-art facilities and a highly collaborative research environment with 13 Departments across Biology/Physics/Biomedical fields. Our lab is co-affiliated with the Departments of “Immunology” and “Developmental and Stem Cell Biology”, facilitating interactions and collaborations in these different research areas.

Recent publications of the lab:

• PDGFRα-induced stromal maturation is required to restrain postnatal intestinal epithelial stemness and promote defense mechanisms. 2022. Jacob et al., Cell Stem Cell, 29(5): 856-868.
• Depletion of slow-cycling PDGFRa+ ADAM12+ mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis. 2023. Di Carlo et al., Nature Immunology, 24(11):1867-1878.