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therapies before transplantation. In this PhD project, you will develop and evaluate innovative strategies to detect, prevent, and repair oxidative stress–associated injury in high-risk donor livers
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ultrastructural assays to assess: Oxidative stress and mitochondrial function Lysosomal/autophagy flux and waste disposal Inflammatory signalling and complement activation Cell survival, death pathways, and barrier
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focusing on: 1. The systematic identification of PTMs induced by various environmental stresses (oxidative, osmotic, thermal, etc.). 2. The functional characterisation of these modifications on Cohesin and
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, this project will establish baseline intracellular MN concentrations in PBMCs from healthy adults and investigate how individual MNs modulate mitochondrial activity, metabolic pathways, and oxidative stress
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erythrocytes, alongside biomarkers of inflammation and oxidative stress. Using combined laboratory and clinical data, empirically derived algorithms for subphenotype identification will be developed through
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the environment, lifestyle factors and drugs, as well as cellular metabolism and oxidative stress. In this PhD project, you will expand this research to uncover biomarkers of aging, a process driven by DNA damage
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oxidative stress, genotoxicity, inflammatory activation and dioxin-like activity. Establishing and validating air-liquid interface (ALI) exposure systems for the direct exposure of human airway cell models
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the CV and/or in the motivation letter; Experience in disease mechanism, particularly in oxidative stress and DNA damage responses - information provided in the CV and/or in the motivation letter