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Field
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-cell omics approaches (scRNA-seq, scATAC-seq, scCUT&Tag) to identify and characterize novel molecular mechanisms driving neurodegeneration in Alzheimer’s Disease. He/she will integrate the single-cell
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Your position You will develop generative models on single-cell and spatial genomics data, from sequencing and imaging, and apply them to human developmental and disease biology. Possible research
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characterisation, and computational modelling to investigate the relationship between matrix properties and osteogenesis. This will contribute to deciphering the importance of mechanical stimulation of the cellular
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instability remains poorly understood. This project will use advanced human cell models, molecular and imaging approaches to investigate how extracellular vesicles and other signalling mechanisms drive
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-extrinsic mechanisms of resistance to KRAS inhibition, including fibroblast-mediated mechanisms, across genetically distinct PDACs. We will prioritise PDAC genotypes for which we already have preliminary data
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fully funded 3.5 PhD (GTA) starting in January 2027 for the following disciplines; Biochemistry, Cell Biology, Chemistry, Computational Biology, Genetics, and Sports, Exercise and Rehabilitation Sciences
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are you going to do? The project addresses a central question in mechanobiology: how do cells sense, encode and respond to mechanical cues? You will develop a quantitative and predictive framework
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and molecular biology approaches, flow cytometry, and transcriptomic and epigenomic analyses. The ultimate goal is to identify the mechanisms driving the age-associated loss of stem cell function and to
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that communicate dynamically in specific tissue niches. Our laboratory has an interest in resolving the interactions between tissue-resident immune cells, with the overall goal of identifying key mechanisms that can
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chemical permeation enhancers, ultrasound, and microneedles. Studies have also shown that mechanical stimulation via nanostructured surfaces can temporarily open tight junctions, allowing large therapeutic