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. Genetic dissection of salamander neural circuits is now feasible with methods for manipulation, elimination, and visualisation of cells. Such approaches can be combined with neuroscience tools such as
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, descending projections to the MLR were uncovered (Ryczko et al. PNAS 2013, PNAS 2016, J Neurosci 2017, J Neurosci 2020). In lamprey, this descending pathway increases locomotor activity. In mammals, the role
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