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highly motivated to define fundamental mechanisms underlying malignancy and translate these findings towards the clinic. Position Requirements Proficiency in genetic modification, cell & molecular biology
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to lead a project focusing on methods to measure non-canonical post-translational modification and on defining their functional role in cancer and normal cell homeostasis. In addition, the postdoctoral
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plasticity. The key requirement for this position is recent Ph.D. training in cancer biology, cell biology, molecular genetics, or epigenetics. Familiarity with cancer models (tissue culture and/or animal
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vulnerability for potent cancer targeting. We develop Targeted Protein Degradation (TPD) therapeutic strategies to abrogate or rewire cancer cell signaling. We have recently established a new discovery platform
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. Despite harboring an elevated burden of mutation-associated antigens (neoantigens) capable of eliciting T cell responses, tumors in the models were not immunogenic, which we showed was due to profound
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-host cell interactions, using integrative techniques from metabolomics, biochemistry, and neuroscience to dissect the bi-directional metabolic exchange processes that support tumor growth and suppress
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organ 3D imaging at single cell resolution of the disease (PMID 34788609). This now allows them to map and functionally probe the neuro-metastatic interface (reviewed in 32302564). The work is a close
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hematopoietic cell development and hematologic cancers. Based on these basic mechanistic insights, the Laboratory is building innovative therapeutics to treat hematopoietic cancers that are currently without
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on understanding the host-immune cell interactions and the mechanisms by which the immune system and tumor microenvironment play a role in the biology and anti-tumor response of liver metastases. More specifically
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Phosphatases and the Regulation of Cell Signaling: from Basic Research to New Therapeutics The protein phosphatases are critical, specific regulators of signaling that serve an essential function, in a