23 Feb 2024
Job Information
- Organisation/Company
J. Heyrovský Institute of Physical Chemistry of the CAS, v. v. i.- Research Field
Chemistry » Computational chemistry- Researcher Profile
First Stage Researcher (R1)- Country
Czech Republic- Application Deadline
2 Apr 2024 - 23:00 (Europe/Prague)- Type of Contract
Temporary- Job Status
Full-time- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
The Timr group at the J. Heyrovský Institute of Physical Chemistry in Prague offers a PhD position in computational biophysics and biomolecular modeling.
Are you fascinated by the complexity of the interior of living cells? Do you enjoy constructing models of proteins and other biomolecules in the computer? Would you like to use the tools of physics, chemistry, and mathematics to describe processes in cells?
Our research group focuses on the computer simulation of the cell interior. Using multi-scale computational models, we aim to elucidate the physical and chemical mechanisms governing the organization of metabolic pathways in living cells. Supported by the Lumina Quaeruntur Award and a grant from the Czech Science Foundation, our team is integrated into the interdisciplinary Department of Computational Chemistry . This department bridges the physical chemistry and biophysics of proteins and membranes with theoretical enzymology and spectroscopy.
PhD project: Computational modeling of dynamic enzyme assemblies
In living cells, various enzymes have been found to assemble into transient structures, appearing and disassembling in response to external conditions. Such dynamic enzyme assemblies, identified in processes like glycolysis and purine synthesis, play an important role in regulating cellular metabolism. They potentially act as switches between competing metabolic pathways. However, the mechanisms behind the formation and functionality of these assemblies are yet to be fully elucidated. This project will explore dynamic enzyme assemblies through a combination of atomistic, coarse-grained, and kinetic modeling, closely integrated with experimental data. The student will characterize the molecular interactions that promote assembly formation and investigate how the crowded environment within these assemblies impacts the transfer of substrates between consecutive enzymes in a pathway. The computational methodologies developed in this work will serve as a basis for the prediction of metabolic fluxes from the composition and architecture of a dynamic enzyme assembly. Thus, the project will enhance our understanding of the regulation and control of metabolic pathways in cells, offering insights into their adaptability and efficiency.
Starting date: Summer 2023 (no later than October 1)
Type of contract: Temporary
Job status: Full-time
Requirements:
The candidates are expected to hold an MSc (or an equivalent) in physics, chemistry, or a related field before the start of the position. They should be interested in biomolecules, capable of formulating mathematical models, and motivated to learn new things. Moreover, they should possess good computer skills and be fluent in English. Experience with molecular simulations and programming will be a plus. The successful candidates will enroll at Charles University in Prague, the top-ranking university in the Czech Republic.
We offer:
- 5 weeks paid leave of absence (holidays) per year + 3 days of paid sick-leave in addition to the statutory insurance
- Flexible working-time, the possibility of part-time work
- Lunch vouchers
- Possibility of attending children groups of the CAS
- Sports goods rental, free parking, trade union library
- Language courses
- Possibility of further education and career development by participating in courses organized by our institute.
Eligibility criteria:
To apply, please send your CV, a motivation letter, transcripts of all courses and grades, and contact information for two references to [email protected] and [email protected] . In your motivation letter, please explain how the proposed research aligns with your interests and why you believe you are a good fit for the position. Please include SC2024_12in the email subject line. For any inquiries, contact [email protected] .
Selection process
By providing us with your personal data in your CV, you have allowed J. Heyrovský Institute of Physical Chemistry to process and file your CV in the HR database. Your personal data will be used for the internal HR needs of the J. Heyrovský Institute of Physical Chemistry only. At the same time, you confirm here that the personal data as stated in the CV you have sent to us is true and accurate.
Requirements
- Research Field
- Chemistry
- Education Level
- Master Degree or equivalent
- Research Field
- Physics
- Education Level
- Master Degree or equivalent
Additional Information
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- J. Heyrovský Institute of Physical Chemistry of the CAS, v. v. i.
- Country
- Czech Republic
- Geofield
Where to apply
[email protected]
Contact
- State/Province
Czech Republic- City
Prague 8- Website
http://web.jh-inst.cas.cz/- Street
Dolejškova 2155/3- Postal Code
182 23
[email protected]
STATUS: EXPIRED
Similar Positions
-
Ph D Student In Organic Chemistry In The Area Of Studies In Sustainable Synthesis Of Composite Materials, Stockholm University, Sweden, 3 days ago
Ref. No. SU FV-0870-24 at the Department of Organic Chemistry . Closing date: 23 April 2024. The Department of Organic Chemistry has an extensive research program, covering many areas of experimen...
-
Ph D Student In Vascular Cell Biology/Immunology, Leiden University, Netherlands, 6 days ago
Apply now The Faculty of Science and the Institute for Biology Leiden are looking for an: PhD student in vascular cell biology/immunology Key responsibilities The PhD student will work in close co...
-
12 Ph D Positions (F, M, D), Georg August University of Göttingen, Germany, about 18 hours ago
12 PhD Positions (f, m, d) Stellen-ID: 2805 Facility: Research Training Group (RTG) 2756 Contact person: Prof. Dr. Sarah Köster [email protected] 0551 39-29429 Date of filling: 0...
-
Ph D Student In Vascular Cell Biology/Immunology, AcademicTransfer, Netherlands, 24 days ago
PhD student in vascular cell biology/immunology PhD student in vascular cell biology/immunology Published Deadline Location today 21 Apr Leiden The Faculty of Science and the Institute for Biology...
-
Ph D On Graphene(Oxide) Colloids From Pyrolysis Carbons, Eindhoven University of Technology, Netherlands, about 22 hours ago
Are you passionate about the energy transition, reducing CO2 emissions, and recycling? Then you may enjoy the challenge of upcycling of solid carbons captured during hydrogen production by (bio)me...
-
Ph D Candidate (M/F/D) Spatial Lipidomics And Structure Elucidation, Leibniz, Germany, about 14 hours ago
The Leibniz-Institut für Analytische Wissenschaften - ISAS - e. V. develops efficient analytical methods for health research. Thus, it contributes to the improvement of the prevention, early diagn...