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) from bacteria. To test the effects of these EVs, you will be using the model organism C. elegans. This work involves the use of classical genetics, transgenic reporter strains and proteomic and
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the molecular biology of aging and neurodegenerative diseases. Engage in the development and testing/validation of new algorithms and their applications to transcriptomic, epigenomic, genetic, and proteomic data
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. Perform in vitro studies with primary lung cell culture models. Perform biochemical or imaging experiments pertaining to CF or e-cigarette exposure. Use imaging, biochemical, proteomic, and microbiological
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) Development and use of optical sensors to understand neuromodulation,(iv) Molecular and cellular mechanisms of GPCR signaling and trafficking (v) Genetic and proteomic screens to identify novel GPCR regulators
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are aimed at and include: Study of global effects of Fmp40 on protein oxidation and cellular metabolome: i) large-scale proteomic analysis to assess protein oligomerization and complex formation via S–S
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systems will be considered an advantage. Experience with ChIP-seq, proteomics, sequencing data analysis and comparative genomics will also be viewed positively. Proficiency in programming languages such as
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disease. Apply and optimize advanced spatial biology techniques, such as spatial transcriptomics, proteomics, and multiplexed imaging, to analyze brain tissue. Lead data analysis and interpretation
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the mechanism of action of the most promising compound. To this end, we will examine the influence of this compound on the transcriptome, proteome, and metabolome of GBM cells. Multiomics, an approach
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, proteomic, transcriptomic, imaging, biochemical and/or physiological experiments to elucidate factors critical for important insect traits (digestion, feeding, development, reproduction, DNA repair, etc
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models. Experience in molecular biology, CRISPR based cellular models, long-read sequencing, confocal microscopy. Experience in mass spectrometry, chemical proteomics or lipidomics, sample preparation and