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(e.g., scRNA-seq) to investigate cellular heterogeneity, host-pathogen interactions, and immune responses. Structural Bioinformatics & Biophysical Modeling: Protein structure prediction (e.g., AlphaFold
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regulation of protein-protein interactions and biochemical activities at the mitochondrial level (see Gökerküçük et al., Autophagy 2023 DOI: 10.1080/15548627.2023.2179845; Jolivet, Desmaison et al., Adv Sci
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, and therapeutic engineering. Projects may involve immunotherapy models, CRISPR-based perturbation and screening, mRNA therapeutics and vaccines, protein engineering, systems immunology, and tumor
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clinical collaborators. Responsibilities Maintain and engineer mammalian cell lines, including transfection, gene knockdown and knockout, and functional assays Perform protein biochemistry, including western
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on developing novel neural network approaches to predict protein conformational dynamics from fixed protein structures, addressing fundamental challenges in structural biology with broad applications in
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. These positions are NIH funded and will involve investigating molecular genetic studies and functional characterization of Ehrlichia chaffeensis genes and proteins involved in regulating the bacterial gene
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will also be determined by the funding available. About you You will hold a PhD/DPhil, or be close to completion of a PhD/DPhil in a related discipline. You will have experience in recombinant protein
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, purify, and titrate lentiviral particles. They will perform lentiviral transduction to generate stable cell lines, assess expression by flow cytometry, and run large-scale cell culture and protein
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will actively participate in research, teaching, and administration, which includes: Research on Taste GPCRs: Investigating the molecular mechanisms of G-protein-coupled taste receptors (GPCRs). Analysis
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factors in human and tick cells, and will be tasked to identify and characterize functions of bacterial proteins and cognitive host cell molecules and signaling pathways. In addition, the researcher will