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and analysis of RNA and protein, and characterization of cellular signaling and transcriptional pathways. Experimental approaches may include Western blotting, qPCR, immunofluorescence, flow cytometry
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responses. Structural Bioinformatics & Biophysical Modeling: Protein structure prediction (e.g., AlphaFold, RoseTTAFold, ESMFold), molecular dynamics (MD) simulations, or protein-protein/antigen-antibody
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-based proteomics or related protein-analysis workflows. Experience with fiber photometry, optical biosensors, or in vivo physiological measurements. Experience studying metabolism, hypothalamic circuits
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characterization of pH- and temperature-sensing bioluminescent proteins for application in intracellular biosensors. They will also be involved in other ongoing laboratory projects involving bioluminescent systems
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analysis. ● Prior work on kinase or other signaling-protein conformational dynamics, phosphorylation-driven activation, or allosteric regulation. ● Familiarity with machine learning and deep learning
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protein synthesis in subcellular space. This project investigates how RNA localization and compartment-specific translation contribute to the assembly and maintenance of the primary cilium, addressing a
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participate in research, teaching, and administration, which includes: Research on Taste GPCRs: Investigating the molecular mechanisms of G-protein-coupled taste receptors (GPCRs). Analysis of Structure
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(approximately 50%) to contribute to other aspects of the lab’s research. These aspects include investigating the molecular mechanisms of membrane proteins using an integrative approach combining biochemistry
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(e.g., scRNA-seq) to investigate cellular heterogeneity, host-pathogen interactions, and immune responses. Structural Bioinformatics & Biophysical Modeling: Protein structure prediction (e.g., AlphaFold
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regulation of protein-protein interactions and biochemical activities at the mitochondrial level (see Gökerküçük et al., Autophagy 2023 DOI: 10.1080/15548627.2023.2179845; Jolivet, Desmaison et al., Adv Sci