The INSERM Chair “Regulation of the Immune System” aims to identify new mechanisms regulating the immune system by considering the global context of the host and the tissues in which immune cells reside. The project will be based on studying tissue–immune cell interactions under homeostatic and pathological conditions, particularly during infections, allergies, autoimmune diseases, or in response to vaccination. The approaches developed will combine molecular biology, omics analyses, and bioinformatics, using both experimental models and clinical samples. This chair fully aligns with INSERM’s strategic plan by establishing a continuum between disruptive fundamental research and the understanding of mechanisms involved in human diseases, leveraging the hospital-university environment of the Necker campus, with the long-term goal of improving patient care.
The teaching program associated with the INSERM Chair will focus on fundamental and integrative immunology, with a particular emphasis on interactions between immune cells and tissues. It will address immune system development, mechanisms of immune tolerance, and their dysregulation in allergic and autoimmune diseases. Special attention will be paid to tissue immunity and interactions with the local environment, including metabolic signals. These courses will be aimed at master’s students in biomedical sciences as well as students enrolled in MD-PhD tracks, within fundamental science modules. The program will combine lectures, case studies drawn from translational research, and critical analyses of recent articles, providing students with an integrated view of modern immunology and its applications in human health.
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