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French National Institute for Health Research (INSERM) | Paris 15, le de France | France | about 2 months ago
Understanding how genes and molecular signals coordinate tissue morphogenesis during organism development is crucial for progress in regenerative medicine and tissue engineering. The implications for human health are substantial, encompassing the treatment of degenerative diseases (such as...
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French National Institute for Health Research (INSERM) | Bordeaux, Aquitaine | France | about 2 months ago
Preserving, restoring, or improving human cardio–neurovascular health represents a major global public health challenge. Aging, chronic stress, metabolic disorders, and lifestyle factors contribute to a concomitant increase in cardiovascular diseases and neurological impairments. It is now well...
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French National Institute for Health Research (INSERM) | Toulouse, Midi Pyrenees | France | about 2 months ago
High-dimensional phenotyping techniques, such as proteomics and transcriptomics, provide information on the expression of thousands of proteins or genes at the single-cell level. These 101, rue de Tolbiac 75654 Paris Cedex 13 République Française Tél. +33 (0) 1 44 23 60 00 Page 3 sur 6 advances...
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French National Institute for Health Research (INSERM) | Strasbourg, Alsace | France | about 2 months ago
This project aims to develop innovative strategies for generating osteogenic grafts for the regeneration of congenital or acquired bone defects. The approach is based on the principles of endochondral ossification, seeking to reproduce the key stages of bone development to improve graft...
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French National Institute for Health Research (INSERM) | Paris 15, le de France | France | about 2 months ago
The INSERM Chair “Regulation of the Immune System” aims to identify new mechanisms regulating the immune system by considering the global context of the host and the tissues in which immune cells reside. The project will be based on studying tissue–immune cell interactions under homeostatic and...
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French National Institute for Health Research (INSERM) | Paris 15, le de France | France | about 2 months ago
Obesity affects more than 14% of pregnant women in France and has significant consequences for child development. Beyond its potential effects, the impacts of its management remain largely unexplored. This project aims to study how obesity from the preconception period onward influences the...
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French National Institute for Health Research (INSERM) | Paris 15, le de France | France | about 2 months ago
Immunothrombosis, or the interaction between immune responses and coagulation, contributes to cardiovascular disease by promoting microvascular thrombosis, inflammation, and endothelial dysfunction. Despite the widespread use of antiplatelet drugs, which target only some of the mechanisms...
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French National Institute for Health Research (INSERM) | Paris 15, le de France | France | about 2 months ago
Understanding many complex diseases and designing rational treatments requires research on multiple scales, ranging from molecular events to morphological and functional behaviour at the organ level. The dynamics and spatial organization of signalling pathways can be essential in determining...
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French National Institute for Health Research (INSERM) | La Reunion, Aquitaine | France | about 2 months ago
The CPJ project will be involved in the “Infectious Mechanisms and Zoonosis Control” theme. It aims to further investigate the immunophysiopathology of emerging and recurrent infectious diseases, particularly in tropical island environments. It is based on the study of host-pathogen...
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French National Institute for Health Research (INSERM) | Doubs, Franche Comte | France | about 2 months ago
The maintenance of T cell effector functions in vivo are critical for the success of cancer immunotherapies including Immune checkpoint inhibitors (ICI), cancer vaccine or adoptive cell transfer. Recent findings highlight a central role for CD4 help in the success of ICI and adoptive cell...