Understanding many complex diseases and designing rational treatments requires research on multiple scales, ranging from molecular events to morphological and functional behaviour at the organ level. The dynamics and spatial organization of signalling pathways can be essential in determining normal or pathological responses in cells and tissues. This project aims to provide a versatile toolkit for precision imaging at the nanometre scale and with sub-second resolution, compatible with complex systems. This approach will be applied in vitro to study the spatiotemporal organization of fundamental biological functions (division, transcription, trafficking, etc.) in single-celled organisms in various contexts, providing a new test for relevant biomedical questions, such as stress response or antibiotic resistance.
The lead researcher is expected to teach and train students at École Polytechnique/IP Paris, either at the master's level or at the bachelor's level and in the École Polytechnique engineering program. He/she expected to teach biology, biomedical engineering, biophotonics or biophysics for a minimum of 42 hours per year, with the possibility of teaching up to 64 hours per year for an additional salary. He/she will also benefit from an environment conducive to innovation, with the local Drahi-X innovation centre and local initiatives aimed at supporting technology transfer.
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