Understanding how genes and molecular signals coordinate tissue morphogenesis during organism development is crucial for progress in regenerative medicine and tissue engineering. The implications for human health are substantial, encompassing the treatment of degenerative diseases (such as Parkinson's disease and type I diabetes) and the reconstruction of damaged tissue, for which organ transplantation has traditionally been the sole therapeutic option. This research endeavor seeks to elucidate how embryonic signals direct collective cellular movements and tissue organization. It will employ advanced experimental and theoretical methodologies, integrating computational modeling with innovative techniques such as biophysical and optogenetic manipulations, applied to robust animal and organoid models. By uncovering the fundamental mechanisms—both intrinsic (genetic) and environmental (transcellular signals)—that regulate tissue structuring and morphogenesis, this project extends beyond traditional developmental biology and stem cell research, opening new avenues for cell and tissue regeneration with significant implications for human health.
The successful candidate will actively participate in the Master's program in Life Sciences - IMALIS (Interdisciplinary Master's in Life Sciences) at PSL University. This master's program is overseen by the ENS/IBENS biology department, where classes are held. The candidate will deliver lectures in cell and developmental biology, participate in student recruitment panels, and be responsible for tutoring ENS and master's students. Additionally, the candidate will engage in the ENS Biology Department's L3 program and the Medicine-Science program, collaboratively managed by ENS-PSL, the Curie Institute, and the Pasteur Institute. These initiatives aim to develop future physician-researchers of the highest caliber, capable of leading innovative biomedical research.
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