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, enabling new approaches for cancer treatment. A central challenge is to understand and control how different nucleic acids are co-encapsulated within a single nanoparticle and how their organization affects
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receptor-interacting molecules exhibiting synergistic activity and favourable safety profiles, followed by the preparation of their bioconjugates and encapsulation in naturally derived polymers. Subsequent
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conventional nanoparticle fabrication methods, PISA combines polymer synthesis, nanoparticle formation, drug encapsulation within a single reaction process, providing an efficient and scalable route towards
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to serve as building blocks of macrocyclic compounds with the potential to encapsulate a variety of small molecules and ions. The synthesis and supramolecular properties of these receptors are the major
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of advanced nanomaterial synthesis equipment and microfluidic systems, as well as for the preparation, characterisation and optimisation of nanotechnological formulations and the encapsulation of biomolecules
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be tested in in vivo models using nano encapsulation of the compounds to achieve targeted tumor delivery. The project provides interdisciplinary training in molecular biology, cell biology
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to their encapsulation and destruction. Further, designing a supramolecular entity that effectively and selectively captures − and subsequently destroys − a CWA is an inherently multi-dimensional problem, requiring high
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, including that of the cerebellar anlage, and cerebellar alterations of TCF activity through modulating BarHl1 levels. Single nuclei will be encapsulated using the 10x Genomics Chromium platform. Two cDNA
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and metabolic interactions with mammalian cells. Possible project elements include: Microfluidic synthesis of polymer capsules and microgels Encapsulation of enzymatic reaction networks, metabolic
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fabrication of microfluidic devices, the formulation and characterization of hydrogel matrices, the encapsulation and culture of adipose spheroids, and the characterization of engineered microtissues using