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Field
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. To this end, we apply interdisciplinary strategies by integrating immunological and genetic approaches with cutting-edge systems immunology and functional genomics tools, including in vivo CRISPR screening
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University of North Carolina at Chapel Hill | Chapel Hill, North Carolina | United States | about 2 months ago
. Experience with genome editing technologies such as CRISPR is a plus. * For dry-lab applicants: Ph.D.-level training and research experience in analyzing multi-omics next-generation sequencing data is required
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, such as: Macrophage and primary cell culture T cell analyses Western blotting qPCR CRISPR Co-immunoprecipitation experiments The laboratory of Dr. Thirumala-Devi Kanneganti offers a remarkable training
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pluripotent stem cells (hiPSCs). Primary responsibility is to utilize the CRISPR/Cas9 genomic engineering technology to examine the impact of genomic ablation of the candidate target genes on iPSC-CM and animal
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of these small molecules by identifying their cellular targets using cell biological and biochemical approaches. Second goal is to utilize CRISPR/Cas9 genomic engineering technology to examine the impact of
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University of North Carolina at Chapel Hill | Chapel Hill, North Carolina | United States | about 2 months ago
to CRISPR-screens to identify druggable genetic modifiers as part of the Drug Discovery Initiative led by the Eshelman Institute of Innovation. The ultimate goal is for postdoctoral fellows to develop
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using Cre-Lox and AAV-Crispr/Cas9 editing of MP in vivo. The AAV-Crispr/Cas9 approach of editing is in pre-clinical development as a novel therapy for humans with hypertension and heart failure
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published scientific paper. Experience in the analysis of genomics data and next-generation sequencing library preparations such as RNA-seq, ChIP-Seq, are preferred. Any skills with CRISPR genome engineering
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using Cre-Lox and AAV-Crispr/Cas9 editing of MP in vivo. The AAV-Crispr/Cas9 approach of editing is in pre-clinical development as a novel therapy for humans with hypertension and heart failure
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to 1) transiently open the blood brain barrier to improve the delivery of gene-therapy (using customized CRISPR-Cas9 agents) and nano-formulated antiretroviral drugs to the brains of rodent models of HIV