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on CRISPR-Cas to stop the spread of AMR-carrying plasmids in the important pathogen Klebsiella pneumoniae. Proof-of-concept work shows that this is theoretically possible, but challenges remain in discerning
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technologies aimed at assessing, protecting, and repairing donor livers before transplantation. This PhD project is embedded within the multidisciplinary CRISPR-CRYSTAL consortium, bringing together experts in
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alterations impact human lymphocyte development. By combining CRISPR-based genome engineering, induced pluripotent stem cells (iPSCs), and advanced thymus and bone marrow organoid systems, we study both
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: General reproductive biology experience CRISPR/Cas9 experience Electroporation experience Reproductive immunology background, particularly ovarian or uterine tissue Primary cell culture experience Histology
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. The project will use quantitative mitochondrial-tracing approaches, including a recently established HiBiT-based platform, live-cell imaging, CRISPR-engineered cancer models and tumour–stromal co-culture
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involvement across the 3 work packages (snRNAseq, vascular organoids, CRISPR validation). Chronic kidney disease (CKD) affects around 10% of the world's population and drives major vascular remodeling
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, cell biology, and translational medicine. The Researcher will lead and support projects involving CRISPR/Cas9 genome editing, molecular characterization of genetic modifications, transgenic animal
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How much does epigenetic variation contribute to rapid adaptation? This PhD at Utrecht University uses CRISPR/Cas9 and SunTag-based epigenomic editing in apomictic dandelions to test whether
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models and combine them with cutting-edge technologies including CRISPR/Cas9 genome engineering, immunopeptidomics, single-cell multiomics, and functional immunology. The project is embedded in a
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suggesting candidate mechanisms of resistance. The project will combine complementary models and techniques, including co-transplantation of organoids in mouse models, in vivo CRISPR, single-cell RNA