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the mechanisms governing mitochondrial DNA (mtDNA) transmission and maintenance. The project will combine genetic, cell biological, and molecular approaches using both Drosophila and human cell models to uncover
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ultra-long sequencing protocols Detailed knowledge of cancer genomics and key drivers in cancer development Experience with extracting HMW DNA from cell lines and patient material (i.e. blood, tissue
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, proteomics, cell and molecular biology, fluorescence microscopy and advanced high-throughput mutagenesis screening. If you are interested in this project, please select Khmelinskii/Padeken as your group
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. IDRs play critical roles in cell signalling and disease, particularly cancer, but remain difficult to target using conventional drug discovery approaches. By combining cutting-edge research
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funds through FCT/MECI, operation no. 15462, with reference COMPETE2030-FEDER-00914400, in the scientific area of Food Chemistry, under a work contract for a non-fixed term, aiming at the development
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neural stem cell (NSC) niche. Recent studies have revealed key aspects of human rhombic lip (hRL) organization and shown that defects in its development underlie several human syndromes. These findings
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, molecular and cell biology analyses, cell bioassays, confocal and time-lapse microscopy, translation-efficiency analyses, ISR/RSR/mTOR signaling studies, and work to defined biological models of drug action
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) is a research institute located in Bordeaux, France, and jointly operated by the CNRS and the University of Bordeaux. It conducts fundamental research in biochemistry, cell biology, and genetics, with
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of an uncertain term contract celebrated under the Labour Code, of 1 (one) doctoral researcher position initial level under private law, for the exercise of scientific research activities in the scientific area of
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the context of additional datasets (RNA-seq, ChIP-seq, ATAC-seq, protein interactome, etc.) to investigate the impact of lamin mutations on spatial genome organization in lipodystrophy patient-derived cells