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Field
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the presence of a cancer cell immobilized on the chip by quantum-tunneling current fluctuations. Experimental studies are complemented by two key theoretical and computer modeling pillars: extensive all-atom
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system. It is these same detectors, in particular the protein called cGAS, which will recognize the cytosolic DNA of cancer cells and, after STING protein activation, alert the immune cells. But how can we
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”. They showed that the tumor microenvironment enforces the production of aberrant proteins in cancer cells (Bartok et al., Nature 2021; Champagne et al., Molecular Cell 2022; Pataskar et al., Nature 2022; Yang
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, bioinformatics, cancer precision medicine, proteogenomics and network analysis to develop methods that transition analysis from cohort-level to patient-specific protein-protein interaction networks, using in-house
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Transient protein-protein interactions (PPIs) control all cellular processes relevant to health and disease. Thus, a major problem in life-sciences research is to understand and manipulate PPIs with
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protein homeostasis which are important for a number of aging-related diseases, including neurodegeneration, and several forms of cancer. The research group of Professor Christian Kaiser , which just
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interventions against protein misfolding and perturbed protein homeostasis which are important for a number of aging-related diseases, including neurodegeneration, and several forms of cancer. The research group
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Primary supervisor - Dr Amit Sachdeva Secondary supervisor - Prof Andy Cammidge Over the last decade, several antibody-based biotherapeutics have been developed for treatment of cancer
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detail, you will contribute to a further understanding of the role of DNA repair and metabolisms proteins in cancer and characterize small molecules inhibiting these pathways and proteins involved using
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proteins in cancer and how protein misfolding and aggregation result in amyloids. Recent results have shown that amyloids formed by the protein alpha-synuclein, which is linked to Parkinson's disease, can