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Details Title Postdoctoral Fellow in Computer Science — From Theory to Practice: Reinforcement Learning for Large Scale Foundation Model Post‑Training School Harvard John A. Paulson School of
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and the Ascidian Ciona to understand the molecular, cellular and neuronal mechanisms of pressure sensation. The comparative analysis will require the use of high-end techniques in neurobiology including
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Research Council. The project will explore how communication between astrocytes and glioblastoma cells influences neuron-to-glioma synapse formation and which molecular mechanisms determine these
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patient-derived organoids. •Co-culture of glioblastoma cells with various components of the tumour microenvironment, including neurons and astrocytes derived from iPSCs or isolated from mouse models
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individual neurons. bioRxiv doi: 10.1101/2020.12.07.414060 Wang G*, Simon D*, et al. Structural plasticity of actin-spectrin membrane skeleton and functional role of actin and spectrin in axon degeneration
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biological reference point for identifying disease-specific biomarkers. A central part of the project is the use of iPSC-derived models, including oligodendrocytes, astrocytes, neurons and myelinating
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these devices to interface with human neural cell cultures in vitro. You will investigate how 3D hydrogel bioelectronic structures can support and guide neuronal growth while enabling electrical recording and
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will investigate compounds targeting a specific signalling pathway to promote axon regeneration. Candidate compounds will be identified through computational screening and human-derived neuronal culture
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, which can be treated with a combination of vitamins related to this pathway, which is currently being tested in clinical trial. In particular, our data point to the importance of folate for neuronal
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The tasks to be carried out by the hired individual include: Behavioral experiments to assess itch in CPT1C knockout models Electrophysiological recordings (current-clamp and voltage-clamp) from neuronal