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animal electrophysiology. Familiarity with epilepsy, seizure dynamics, ictogenesis, neuromodulation, or neural network analysis. Experience with small-animal stereotactic surgery, viral-vector
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and blood-borne pathogen/viral vectors regulatory requirements. The ideal candidate will be willing to commit for at least a one-year period. Among the key duties of the position are the following
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microinjections of DIO viral vectors into brain, immunohistochemical analyses, as well as assays for behavioral phenotypes to identify brain circuits responsible for neuropsychiatric disorders associated with
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, performing small craniotomies for injection of chemical and viral vectors, and for implantation of multiple stimulation and recording electrodes. Designs, executes, and analyzes research studies using
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genetically modified mice, performs stereotaxic brain surgeries to delivery gene therapy through viral vectors or recombinant proteins, analyzes brains using morphological and biochemical assays including
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expertise in recombinant DNA technology, infectious agent handling, and vector systems. Essential competencies include conducting rigorous, evidence-based risk assessments (hazard identification, exposure
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, and cellular therapy. This research includes cell culture, transduction, transfection, retroviruses, lentiviruses, construction of vectors and DNA cloning, flow cytometry, cytolysis assays, cytokine
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animal experiments using mice, performing small craniotomies for injection of chemical and viral vectors, and for implantation of multiple stimulation and recording electrodes. Designs, executes, and
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neuropathological materials. Perform molecular biology experiments that involve cloning of specific cDNAs in various vectors including viral vectors, PCR, sequence analyses, transcription assays, Western blotting
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biology, cell biology, and in vivo behavioral experiments. Generation of lentiviral vector for in vivo or in vitro gene delivery; primary neuronal culture; human fibroblast and pluripotent stem cell culture