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Field
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of these compounds in primary human GBM cells stratified according to their transcriptomic subtype and derived from patients of different sex. Subsequently, we will decipher the molecular target or at least
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; cloning; microdissection, especially of insect female reproductive organs; statistical analyses; single-cell RNA sequencing and transcriptome analysis; genetic mapping including QTL, GWAS, or PhyloG2P
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utilizing ex vivo airway epithelial cell models, including air-liquid interface (ALI) culture systems. Experience analyzing and interpreting transcriptomic datasets (e.g., RNA-seq). Experience working with
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, glial, and immune cell culture, nucleic acid extractions, ELISAs, bead-based microarrays, immunohistochemistry, spatial transcriptomics, and molecular analyses. The candidate will summarize research data
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of neurodegeneration, totaling to over 1,500 human brain samples. Using an array of -omics techniques, e.g. long read DNA sequencing, single nuclei transcriptomics & ATACseq and multi-modal proteomics, the team aims
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RNA metabolism in iPSC models of ALS/FTD. Carry out NextGen sequencing experiments and data analysis to determine epigenetic and transcriptomics changes in iPSC models of ALS/FTD. Carry out experiments
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translational studies, and innovative technologies including spatial transcriptomics, single cell RNA-sequencing, and induced-pluripotent stem cells, we are interested in determining how reactive oxygen species
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, brain organoids, genome editing, high-resolution imaging, single-cell sequencing, spatial transcriptomics, epigenomics, and proteomics, as well as a unique mouse model in which neural progenitors acquire
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, transcriptomics, metabolomics, phenomics, microbiome) for predictive modeling and biological interpretation. •Proficiency in Python, R, AI/ML frameworks, and bioinformatics pipelines for high-throughput data
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statistical learning frameworks to decipher single-cell and spatial transcriptomics data, with the goal of uncovering cellular and tissue dynamics underlying cancer, inflammation, and tissue senescence