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to the discovery of dozens of classes of bacterial riboswitches and other structured noncoding RNAs. We are now applying similar genome-scale discovery methods to identify functional RNA regulatory elements in
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of in vitro and in vivo drug efficacy assays to validate mechanisms of acquired resistance and test novel combinations. Development and validation of liquid biopsy technologies and ctDNA analytics
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their emotional intelligence. Our work focuses on: (1) the development and impact of social and emotional skills among diverse populations, including education settings and organizations, and (2) the mechanisms by
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Templeton Foundation. The project seeks to discover and characterize novel RNA-based gene regulatory mechanisms in mammals, with a particular focus on riboswitches that sense lithium and sodium ions
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, psychiatry, and clinical research to study the mechanisms, safety, and therapeutic potential of novel and established compounds across the lifespan. With over two decades of continuous NIH- and VA-funded
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these departments, the Hoffman lab focuses on understanding biological mechanisms in neurodevelopmental disorders with a focus on ASDs. To do this, we study the function of genes that are strongly associated with