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-sputum whole-genome sequencing within the DiSrupT RR-TB trial. The clinical trial will evaluate a multi-component intervention to reduce the transmission of RR-TB. A key component of the intervention is a
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of neurodegeneration, totaling to over 1,500 human brain samples. Using an array of -omics techniques, e.g. long read DNA sequencing, single nuclei transcriptomics & ATACseq and multi-modal proteomics, the team aims
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, including qPCR, DNA/RNA sequencing, flow cytometry, fluorescence microscopy, plasmid design, production and in vitro transcription of mRNA is key. Prior experience with gene editing protocols and read-outs is
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