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position on interactions between neuronal activity and cardiac function in zebrafish larvae, using advanced whole-brain functional imaging and cardiac monitoring. The work involves transgenic lines and
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measures across multiple zebrafish models of leukodystrophy, including models of RNASET2 deficiency, adrenoleukodystrophy (ALD), Krabbe disease and metachromatic leukodystrophy (MLD). Zebrafish are widely
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brain circuits, but the role of protein synthesis in this key developmental process is still poorly understood. Using zebrafish and mouse models, this project will compare ribosomes in progenitors and
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direction of the head of the fish facility, this position is responsible for the daily care and husbandry of zebrafish in a research environment in accordance with all applicable laws and regulatory
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. In this project we will study the functions of the rare coding variants using zebrafish and compare the results with mouse models of equivalent mutations and human post-mortem brain tissue
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discipline to join the Microbiome-Brain-Gut Axis research programme at APC Microbiome Ireland and University College Cork. The successful candidate will join the Research Ireland funded project focussed
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brain at cellular and millisecond resolution. By combining advanced microscopy, genetically encoded voltage indicators, two-photon optogenetics, and zebrafish neuroscience, we aim to enable causal
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projects: In vivo functional analyses of neurodevelopmental disorder risk genes at the behavioral, brain structural, and activity levels in zebrafish Developing novel multi-omics platforms in zebrafish
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will gain knowledge and experience in zebrafish neurobiology and husbandry, genetics, behavioral assays, brain imaging, and pharmacological screens. Training The Postgraduate Associate will also gain
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Postdoctoral Researcher with a background in Neuroscience, Pharmacology, Physiology, Biomedical Science, Microbiology or a related discipline to join the Microbiome-Brain-Gut Axis research programme at APC