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Field
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Postdoctoral Associate | Mitochondrial Genomics | Lake Lab — Yale University, Department of Genetics
our research please see our website: https://www.thelakelab.org/ Responsibilities Generate and characterize novel cellular models of mitochondrial genome dysfunction using genome-editing and related
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and lignocellulosic biomass into domestic fuels and chemicals. Research activities may include creating transformation methods, constructing gene‑expression “genetic parts,” and developing CRISPR‑Cas
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pharmacology to map neuroimmune circuits from the molecule to the whole organism. We also have an increasing interest in human immunology and neuroscience and are building the resources (iPSC cells, CRISPR
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and optimizing CRISPR/Cas9 delivery methods. You will also assist the maize transformation team when needed and work closely with colleagues in the lab and in our greenhouses facilities located in
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plant transformation, cloning (restriction enzyme-based, infusion PCR-based, and gateway), quantitative real-time PCR, CRISPR-Cas9 based genome editing and time-lapse confocal microscopy on Arabidopsis
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cultures Cell and molecular biology Hands-on laboratory techniques, including: CRISPR gene editing Immunocytochemistry Migration and chemotactic assays Microscopy About the Department Family Medicine and
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oncogenic cell states. To investigate these questions, we combine molecular biology, cancer biology, and genomics, including long-read RNA sequencing, RNA-targeting CRISPR, and computational analysis. We
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, including tissue culture (cell line, primary cell, stem cell), mouse handling, mouse model creating (transgene, knock-in, knock-out), gene therapy/editing techniques (CRISPR, TALEN, Zinc finger) in vitro and
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execution of novel genetic modification techniques in C. elegans models of disease to investigate biological mechanisms, such as implementation of CRISPR, RMCE, and classic irradiation based integration
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biology, genome engineering, CRISPR-based screening, functional genomics, or C. elegans genetics are particularly encouraged to apply. Minimum Education and Experience Ph.D in a related field. Candidates