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Primary supervisor - Dr Amit Sachdeva Secondary supervisor - Prof Andy Cammidge Over the last decade, several antibody-based biotherapeutics have been developed for treatment of cancer. These antibodies often bind to cell surface receptors on cancer cells and direct them towards apoptosis...
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Group B Streptococcus (GBS) is an effective pathogen of humans and animals and is well known as the leading cause of often-fatal infections in newborn infants. Little is known about how GBS resists the immune system and colonises to cause invasive disease. This PhD will develop a new...
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Primary supervisor - Dr Fred Warren The infant gut is a complex, constantly adapting ecosystem which shows distinct shifts as a consequence of introducing solid foods, which can have lifelong health impacts. An important nutrient in weaning foods is starch, a key dietary component in the adult...
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PhD Studentship: The Role of the Extracellular Matrix in Cardiomyocyte Developmental (SMITH_U24DTP1)
Primary Supervisor: Dr James Smith Cardiomyocytes are the muscle cells of the heart, responsible for the production of contraction forces. During development, cardiomyocytes withdraw from the cell-cycle and switch from proliferative, growth to non-proliferative, hypertrophic growth. It is...
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Primary supervisor - Professor Diane Saunders Wheat blast and rusts are fungal diseases that severely damage cereal production worldwide. During infection, these fungi secrete proteins into wheat plants to reprogramme host plant circuitry, supporting their own growth and development. A subset of...
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Primary supervisor - Professor Martin Warren This PhD opportunity is ideal for graduates in biochemistry or biomedical science with a keen interest in protein science and its application in developing new diagnostic tests and assays. Recently, the National Institute for Health and Care...
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Primary Supervisor: Dr. Rebecca Taylor Ageing is associated with increased rates of disease, including neurodegenerative conditions. Prion-like proteins (PrLPs) play major roles in age-associated neurodegeneration, but their physiological functions are often poorly understood. Defining these...
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Primary supervisor - Dr Paul Crichton Mitochondria in our cells harness energy through the breakdown of nutrients to produce ATP through oxidative phosphorylation. However, in specialised brown adipose tissue, popularised as ‘good fat’, the conventional process is ‘short circuited’ by a...
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Primary supervisor - Dr Myriam Charpentier Nitrogen (N) acquisition is fundamental for plant growth. However, N is poorly available in soils, leading to extensive and costly chemical fertiliser applications. It is estimated that 50-70% of nitrogen-derived fertilizer provided to the soil is lost,...
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Primary supervisor - Dr Andrew Gates As well as carbon dioxide (CO2), other important climate-active gases are known to drive global warming. Importantly, nitrous oxide (N2O), is the third most abundant greenhouse gas with 300-times greater global warming power than CO2 and it also contributes...