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encoded FRET biosensors for mitochondrial functionality. - Implement innovative data analysis protocols and approaches for FRET/FLIM or radiometric FRET microscopy in cultured cell lines - Modify and/or
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binding assays, bioluminescent and fluorescent resonance energy transfer (BRET/FRET) and proximity ligation assays, protein purification techniques, enzymatic activity assays, PCR/qPCR, DNA cloning. Cell
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allosteric coupling, to exquisitely control signal routing. We integrate structural biology (NMR, X-ray, cryoEM) and biophysical techniques (FRET, ITC, BLI) with cellular readouts (TopFlash, BRET) and
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in fluorescence resonance energy transfer (FRET) assay to study protein-protein interactions. Skills for handling biochemical issues and experimental techniques. Good knowledge of the English language
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to characterise binary and ternary complex formation, including TR-FRET, AlphaLISA, SPR (Surface Plasmon Resonance), ITC (Isothermal Titration Calorimetry), and NanoBRET. Pursuing co-crystal structures of BromoTag
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Working with biophysical assay data (e.g. SPR, TR-FRET, AlphaLISA, ITC, NanoBRET) to guide compound design and prioritisation Use of analytical chemistry techniques relevant to probe characterisation (HPLC
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and test the propensity for nucleating cracks in laboratory experiments. You will be responsible for the design and performance of fretting fatigue, plain fatigue and wear tests using bespoke servo
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University of North Carolina at Chapel Hill | Chapel Hill, North Carolina | United States | 25 days ago
kinetic analyses, structural biology, and FRET/BRET measurements. Minimum Education and Experience Requirements PhD in the Biological or Chemical Sciences. Required Qualifications, Competencies, and
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, crystallography, cryoEM, binding kinetics. Biophysical Imaging: Single-molecule FRET, super-resolution, single-particle tracking, TIRF, confocal microscopy. Programming skills preferred. Accompanying Knowledge
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deconvoluted with single-molecule precision . Single-molecule analysis of ligand efficacy in β2AR-G-protein activation. Single-molecule FRET imaging of GPCR dimers in living cells Quantifying secondary transport