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mutation to a unique DNA barcode, we can track variants across large cell populations and quantify their functional effects through high-throughput screens. This powerful connection between genotype and
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research and to drive in vitro drug target and mechanistic discovery efforts using 3D triple culture system based on iPSCs. The cell lines will be derived from participants of the Flemish Cognitive Compass
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well as public databases. Expertise in the data analysis of one of the modalities that we will use in this project (single cell transcriptomics, ATACseq, proteomics or long-read DNA or RNA sequencing) will
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state-of-the-art approaches including single-cell and spatial transcriptomics, circuit tracing and connectomics, and automated behavioral analysis. In close collaboration with the Verstreken and de Wit