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of additional datasets (RNA-seq, ChIP-seq, ATAC-seq, protein interactome, etc.) to investigate the impact of lamin mutations on spatial genome organization in lipodystrophy patient-derived cells. You will be
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spoken English. Additional qualifications: Experience with NGS techniques (RNA-seq, ChIP-seq, WGBS, etc.); Experience with chromatin conformation analysis techniques (Chromosome Conformation Capture-based
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-disciplinary team and will be trained in biochemistry, molecular biology, proteomics, genomics (ChIP-seq, RNA-seq, ATAC-seq etc) in cell and primary disease models. This PhD role will also be embedded in a
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(wet-lab & computational) PhD student to work on a Project focused on Understanding the Role of RNAs in Alzheimer's Disease Pathology. In this project, the selected PhD candidate will combine
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International Centre for Translational Eye Research / Institute of Physical Chemistry, Polish Academy of Sciences | Poland | 7 days ago
tissue dissection, Preparing tissues for spatial transciptomic studies, Optimization of protocols for multimodal analyses (RNA-seq, ATAC-seq) of single cells, Executing, analyzing, and interpreting
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, CRISPR-Cas9, single-cell RNA sequencing (scRNA-seq) and bulk RNA sequencing (RNA-seq), multispectral imaging, immunohistochemistry, Western blotting, tissue culture, genotyping, and qPCR. Under
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accessibility and gene activity, using advanced genomics approaches such as CUT&Tag and RNA-seq, we can uncover how disrupted gene control leads to neurodevelopmental disorders including intellectual disability
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of additional datasets (RNA-seq, ChIP-seq, ATAC-seq, protein interactome, etc.) to investigate the impact of lamin mutations on spatial genome organization in lipodystrophy patient-derived cells. You will be
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the context of additional datasets (RNA-seq, ChIP-seq, ATAC-seq, protein interactome, etc.) to investigate the impact of lamin mutations on spatial genome organization in lipodystrophy patient-derived cells
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libraries will be generated: one for 3′ SN RNA sequencing and one for SN ATAC-seq. Sequencing will be performed using short-read, paired-end sequencing, with sufficient depth to detect approximately 3,500