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of the molecular and cellular events that lead to vascular calcification in chronic kidney disease. Animal models for chronic kidney disease or diabetic mice will be performed to mimic human relevant diseases. By
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involvement across the 3 work packages (snRNAseq, vascular organoids, CRISPR validation). Chronic kidney disease (CKD) affects around 10% of the world's population and drives major vascular remodeling
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on psychological assessment of learning and attention disorders and neuropsychological testing with youth with various medical conditions (including seizures, cancer, and kidney transplant patients). The fellows
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extract is associated with kidney damage, kava extract with liver toxicity, and ephedra extract with cardiovascular insults. These examples highlight the need for a robust and structured strategy to better
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for molecular imaging and targeted therapies. However, their clinical translation is often limited by unfavorable pharmacokinetic properties, including rapid blood clearance and high kidney uptake. This project
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We are seeking a talented research assistant to build and optimise human iPSC-derived renal organoids, using them as a platform to decode the molecular mechanisms behind chronic kidney disease (CKD
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developing innovative siRNA‑based therapies. Our research focuses on areas with high unmet medical need, including cardiovascular, metabolic, liver, and kidney diseases. We have access to a strong and