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applicants for a PhD position in Stem cells and Multiple Sclerosis (MS). Your work will focus on human iPSC-based models of inflammation and MS to study microglial cell functioning in a white matter- and grey
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staff position within a Research Infrastructure? No Offer Description Diffuse Large B cell Lymphoma (DLBCL) is the most common aggressive (fast-growing) Non-Hodgkin-lymphoma with heterogeneous clinical
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Alzheimer’s disease such as ApoE4. In this PhD project, you will apply this previous knowledge to develop cellular screening assays in order to identify novel candidate interventions for Alzheimer’s disease
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for a highly motivated and enthusiastic PhD student with: An completed MSc in a relevant field; Preferably a background in stem cell biology and molecular biology. Experience with retinal or relevant
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of macrophages; Next to cell culture experiments, you will use and analyze state-of-the-art approaches such as RNA-sequencing and ChIP-sequencing analysis; Translate your findings to disease models; Align
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complications. While cell death and necrotic core formation associate with plaque instability and poor clinical outcome, fibrous-cap formation and thickening is associated with increased plaque stability in
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this collaborative project, we will investigate the mechanisms of tRNA gene regulation using novel methods and technologies in human cells and budding yeast. We will take advantage of CRISPR-mediated approaches, high
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between immune cells present in choroid plexus (ChP), the cerebrospinal fluid (CSF), the brain parenchyma and surrounding meninges (Rodriguez-Lorenzo et al., eLife 2022; van Olst et al., ACTA Neuropath
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and Siglec receptors and analyze their capacity to block pathogen infection and to target antigens to antigen presenting cells. As a PhD student your main tasks and responsibilities are: Clone