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, 2024). We are seeking an enthusiastic candidate for one of the projects that is funded by ZonMW: Prof P.L. Hordijk - Innovative modelling of the human microcirculation by merging vascular cell biology
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applicants for a PhD position in Stem cells and Multiple Sclerosis (MS). Your work will focus on human iPSC-based models of inflammation and MS to study microglial cell functioning in a white matter- and grey
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staff position within a Research Infrastructure? No Offer Description Diffuse Large B cell Lymphoma (DLBCL) is the most common aggressive (fast-growing) Non-Hodgkin-lymphoma with heterogeneous clinical
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of type 2 diabetes In this project, we will study disrupted communication between fat tissue, capillaries and muscle cells as an early cause of type 2 diabetes. We will create human muscles in a dish from
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sciences or biology; Experience with iPSC models and/or extensive cell culture experience with other cell types; Hands-on experience with CRISPR or assay development is an advantage, but not required
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on the cytokine responses of macrophages; Next to cell culture experiments, you will use and analyze state-of-the-art approaches such as RNA-sequencing and ChIP-sequencing analysis; Translate your findings
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will build on the extensive experience and infrastructure of the Ophthalmogenetics lab with iPSC technology for retinal cell/organoid differentiation combined with the innovative 3D cellular bioprinting
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of macrophages; Next to cell culture experiments, you will use and analyze state-of-the-art approaches such as RNA-sequencing and ChIP-sequencing analysis; Translate your findings to disease models; Align
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between immune cells present in choroid plexus (ChP), the cerebrospinal fluid (CSF), the brain parenchyma and surrounding meninges (Rodriguez-Lorenzo et al., eLife 2022; van Olst et al., ACTA Neuropath
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this collaborative project, we will investigate the mechanisms of tRNA gene regulation using novel methods and technologies in human cells and budding yeast. We will take advantage of CRISPR-mediated approaches, high