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Field
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proteins, nucleic acids and their complexes through an integrative structural biology approach. The laboratory combines experimental and computational methods to understand biomolecular structure, dynamics
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traceless activation and radical coupling. The role will focus on selective modification of carbohydrates and glycosides, radical reaction development, synthesis and purification of complex products
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, demonstrating strong proficiency in electronic structure calculations, high-performance computing (HPC), and code development for molecular spectroscopy. This full-time, 3-year position supports the STFC-funded
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to characterise binary and ternary complex formation, including TR-FRET, AlphaLISA, SPR (Surface Plasmon Resonance), ITC (Isothermal Titration Calorimetry), and NanoBRET. Pursuing co-crystal structures of BromoTag
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detailed structural information on active pharmaceutical ingredients (APIs), pharmaceutical cocrystals and salts, formulated drug products, and other complex solid-state systems. Projects will utilize state
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to develop, optimize and apply advanced mass spectrometry approaches for the structural and molecular characterization of ARDCs, and to analyze and interpret the resulting data. - Develop and optimize mass
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actively to discussions, share your insights with others and are willing to support students and junior researchers. You are structured in your approach to complex problems, curious about new methods and
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disordered proteins, nucleic acids and their complexes by integrative structural biology. The laboratory uses and develops state-of-the-art Nuclear Magnetic Resonance Spectroscopy (NMR) methods as a major
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medicines. Research Project: This proposed study investigates the complex micro and nanoscale structures of buprenorphine sublingual films to address the current lack of regulatory guidance on Q3
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encouraged to apply. Our laboratory develops and applies NMR methods - particularly solid-state NMR - to reveal molecular composition, structure, interactions, and chemical modifications in complex biological