Post-Doctoral Researcher - Metabolomics

The Institute of Molecular Systems Biology at ETH Zurich is inviting applications for a Postdoctoral position in the laboratory of Professor Dr Nicola Zamboni .

The group of Dr Zamboni researches the function and regulation of metabolism. In particular, the group is attracted by

• systems in which metabolism or metabolites drive phenotypic differentiation
• problems of biomedical relevance, and
• cases that are especially complex or technically challenging

To tackle such problems, the group adopts cutting-edge mass spectrometry (i.e. metabolomics, lipidomics, and quantitative 13C metabolic flux analysis) and computational methods. The latter range from statistics to deep learning or probabilistic graphical models, and aim at integrating prior knowledge on molecular properties or network topology.

A key focus of the group is on the development of high-throughput methods, which allow to rapidly screen large cohorts of, i.e. clinical samples, drug libraries, or mutant collections. By combining high-resolution, untargeted mass spectrometry and newly engineered software pipelines, the group has become very efficient in analyzing studies with tens of thousands of samples without compromising quality and coverage. Beyond internal R&D projects, the group of Dr Zamboni is heavily involved in external collaborations, both national and international. The group is tightly embedded in the Swiss initiatives on personalized health (PHRT, www.sfa-phrt.ch ). In the near term, the priority challenges are on generating interoperable data across studies, improving the acquisition of possibly informative and deep MS2 data, and enabling the detection of rare compounds.

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