The Department of Biomedicine (DBM) is a joint effort between the University of Basel and the University Hospitals Basel. It unites basic and clinical scientists to advance our understanding of health and disease and to develop pioneering therapies benefiting the lives of patients in areas of unmet need. With more than 70 research groups and 900 employees, the DBM is the largest department at the University located in the heart of Basel. The group for childhood leukemia, affiliated with the University Children's Hospital (UKBB) & the DBM studies genetic alterations involved in the development, maintenance and relapse of acute myeloid leukemia (AML). We use various models to dissect critical cellular and molecular mechanisms of AML initiation and maintenance (Stavropoulou et al. Cancer Cell, 2016; Lopez et al., Cancer Discovery, 2019, Forte et al., Cell Metabolism, 2020; Leonards et al., Nat Commun 2020, Piqué et al., Blood 2023).
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