PhD student position: elucidating chaperone protein function using single-molecule fluorescence/FRET
PhD student position: elucidating chaperone protein function using single-molecule fluorescence/FRET
100%, starting June (negotiable)
The Biomolecular Nano-Dynamics group at the Dept. of Chemistry, University of Basel is looking for a highly talented and motivated PhD student in biophysical chemistry to join our team for the study of protein dynamics and chaperone function using novel techniques, such as single-molecule fluorescence/FRET and unnatural amino-acid labelling.
Your position
This PhD project will grow with you. You will create time-resolved direct observations of single Hsp90 chaperone proteins in action, to push beyond static 3D structures and reveal the essential molecular processes that underlie Hsp90's function, i.e.: to assist protein folding and maturation in health and disease. Multiple critical questions remain unsolved in this regard that you can tackle in your PhD. Steps involved:
- Protein construct design, mutagenesis, purification, bioconjugation, quality control
- Single-molecule fluorescence/FRET/DyeCycling experiments
- Genetic code expansion for site-specific unnatural amino-acid labeling
- Data analysis using existing and self-written code
Your profile
Prior experience in several of these areas is desired:
- Protein biochemistry (purification, bioconjugation, quality control, etc.)
- Single-molecule experiments and interpretation
- Advanced data analysis, coding, machine learning
- Optics and fluorescence microscopy techniques
Essential requirements:
- MSc degree in (bio-)chemistry, physics, molecular lifesciences with excellent grades
- High motivation and curiosity about fundamental questions in protein science
- Independent analytical thinking and systematic work style
- Excellent experimental problem-solving skills and perseverance
- Friendly team player proficient in English communication (speaking & writing)
We offer you
- An exciting and fully funded PhD project in Basel, Switzerland
- Embedding in a productive, interdisciplinary group with an open and interactive lab culture
- State-of-the-art research infrastructure and facilities
- A highly international and interdisciplinary setting stimulating your professional and personal development
- The GRACE graduate center
- A beautiful and very livable city at the intersection of Germany, France, and Switzerland
- Wide-ranging sport offers
It goes without saying that we welcome applications of friendly and ambitious humans of all kind.
Application / Contact
Applications are invited before/by April 7th, 2024.
Please submit your application via [email protected] with subject 'Application PhD3 Firstname Lastname' , and include:
your letter of motivation, your CV, and email addresses of 2-3 references – all merged into one single pdf file named 'Application PhD3 Firstname Lastname.pdf'.
For questions, please contact Prof. Sonja Schmid: [email protected] .
www.unibas.ch
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